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Azuma K, Koumura T, Iwamoto R, Matsuoka M, Terauchi R, Yasuda S, Shiraya T, Watanabe S, Aihara M, Imai H, Ueta T

Adjust interventions: if there is evidence of obstruction or gallstones, imaging / referral may be needed

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A notable example is the placebo-controlled trial by Bhasin et al., which demonstrated dose-dependent anabolic effects of supraphysiological testosterone enanthate administered for 10 weeks in healthy men, providing valuable mechanistic insight under rigorously controlled conditions but without addressing long-term safety outcomes (96)