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Major semaglutide weight loss trials (STEP 14) did not measure cortisol as a primary or secondary outcome
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Dual-action: targets both GLP-1 and GIP receptors Reduces appetite and food cravings Supports greater fullness after meals Helps regulate blood sugar It is also taken as a once-weekly injection
In practical terms, the receptors on any given cell begin losing sensitivity within minutes of sustained agonist exposure
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