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When combined, patients may experience: Excessive appetite suppression , leading to inadequate caloric intake Unintended weight loss beyond therapeutic targets Nutritional deficiencies if dietary intake becomes severely restricted Difficulty maintaining energy for daily activities Hypoglycemia risk in patients also taking insulin or sulfonylureas, due to reduced food intake Gastrointestinal effects may also be compounded
Because of these risk factors, some healthcare providers may choose to monitor vitamin B12 levels in patients being treated for diabetes, particularly if symptoms of deficiency develop
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The most effective approach combines NAC (600-1,200 mg daily) for cysteine, glycine supplementation (5-15g daily) to correct deficiency, whey protein (20-40g daily), selenium (200 mcg), and sulforaphane from cruciferous vegetables
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