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The placebo group had either an increase or no change in oxidative stress, as shown by a significant increase in MDA in RBCs ( Figure 4E ) or no change in MDA in plasma ( Figure 4C ) or PBMCs ( Figure 4D )

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Tapering versus abrupt cessation The clinical trials did not specifically study tapering protocols, but physiological principles suggest a gradual dose reduction may produce a smoother transition than abrupt cessation