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REDEFINE 1 Combination Data The closest analog for layered amylin + incretin tolerability is REDEFINE 1, where cagrilintide 2.4 mg was paired with semaglutide 2.4 mg: The pattern: layering cagrilintide on a GLP-1 backbone produced modestly more GI events than the GLP-1 alone, but discontinuation rates were similar
Nearly half of the respondents report intentionally increasing their consumption of fiber (both soluble and insoluble fibers) since starting GLP-1 treatment, said Brad Schwan, vice president of marketing for ADM
Niu B, Liao K, Zhou Y, Wen T, Quan G, Pan X, Wu C
While this is far from proven, it is a significant scientific clue worth following
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