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The FDA-approved prescribing information recommends gradual dose titration specifically to minimize gastrointestinal tolerability issues, allowing the digestive system time to adapt to the medication's effects on gut function
Some patients initiating semaglutide therapy have reported changes in sexual function, though these reports remain anecdotal and have not been systematically studied in controlled trials
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The submission must address how the drug performs in both clinical trials and clinical practice, focusing on patients with obesity and diabetes who seek effective weight loss solutions
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