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Tumor cell metabolism also generates FFAs that promote fatty acid oxidation (FAO) in TAMs, which in conjunction with lactate produced by anaerobic glycolysis and the enhanced OXPHOS in macrophages, collectively induces the M2 polarization of these cells, leading to the formation of an immunosuppressive tumor microenvironment, further enabling tumor cells to evade immune surveillance and sustain proliferation [302]
Amino acid sequence similarity between malate dehydrogenases (NAD) and pea chloroplast [PMID: 3665938] Laboratory literature summary: Amino acid sequence similarity between malate dehydrogenases (NAD) and pea chloroplast malate dehydrogenase (NADP)
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