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Q: A recent New Yorker article described people who had taken these drugs and reported a side effect of less excitement about life Cummings: There are a lot of hints that the drugs may act in the reward centers of the brain, and those actions may have something to do with why they seem to be associated with lower alcohol and substance abuse and smoking, and other compulsive behaviors like gambling and shopping

How Zepbound and Wegovy Work Differently The most important difference between Zepbound and Wegovy starts with their active ingredients

Study characteristics The included studies were published between 2016 and 2025, with sample sizes ranging from 3,183 to 17,604 participants

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