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For Tirzepatide versus Semaglutide comparative studies, prepare both compounds in matched PBS-BSA vehicles at equivalent molar concentrations and include selective GIPR antagonist controls to confirm GIPR-independent biology of Semaglutide comparator treatments

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Given the above literature, it is surprising that a recent proposal suggests certain enteroendocrine cells, including GLP-1 cells, communicate with vagal afferents through synaptic-like transmission 38,39

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