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Amino acids V12 (putative oxyanion hole), F112 (active site architecture), N108 (flavonoid binding) and C13 (GSH stabilization) were fully randomized by site saturation mutagenesis (NNK codons), and the created Pt GSTF8 variants were tested for conversion of flavan-3,3,4-triol ( 4 ) to cyanidin ( 8 ), and for their GSH-transferase activity towards CDNB ( 5 ) as a control of catalytic competence
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EUROPE, MIDDLE EAST & AFRICA GLUTATHIONE MARKET SIZE, BY SUBREGION, 2018-2032 (USD MILLION) TABLE 280
Functional indicators Reduced appetite suppression: If the same dose that previously suppressed your appetite is suddenly less effective, potency loss is possible
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