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Studies show individuals having higher levels of zonulin, a marker of intestinal permeability (or Leaky Gut), suggests that Leaky Gut may play a role in the development of histamine intolerance

However, metformin can cross the placenta into the fetus, which has raised concerns about its safety and potential adverse effects

doi: 10.3389/fpls.2023.1216682 Summary Keywords glucoraphanin, sulforaphane, Nrf2 signaling, ferroptosis, tumor microenvironment Citation Zhao Z, Chen Q, Qiao X, Wang J, Ali ZTA, Li J and Yin L (2025) Sulforaphane in cancer precision medicine: from biosynthetic origins to multiscale mechanisms and clinical translation

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