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M., Herman, T
Cell therapy can positively influence these changes through paracrine signaling, EV cargo, mitochondrial transfer, antioxidant effects, immune-metabolic reprogramming, angiogenesis, BBB stabilization and support of plasticity
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The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris
