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Hb is necessary for the action of KDS12025 To determine whether astrocytic Hb is the molecular target of KDS12025, we developed short hairpin RNA (shRNA) to silence Hb expression (AAV-pSicoR-Hb-shRNA) in primary astrocytes and determine its efficacy (Supplementary Fig
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This targeted distribution means smaller total doses may deliver therapeutic concentrations where they matter most
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