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128-OR: Effect of tirzepatide on the counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes
Following an apoptotic stimulus, Bax is activated and translocates to the mitochondria, where it undergoes a conformational change and inserts into the OMM
This is significantly more than most other weight loss medications, which typically lead to 5-10% weight loss
The surface accessibility of our engineered disulfide bond contrasts to naturally occurring disulfides, which are generally buried (Dani et al., 2003)
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