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More research is needed to determine the best approach to monitoring and managing these patients once the medication is discontinued. According to Maya and colleagues, current evidence on links between GLP-1s and pregnancy complications remain limited, conflicting and subject to residual confounding by indication or selection and recall bias. They added that if gestational weight gain is a result of GLP-1 discontinuation before or early during pregnancy, negative outcomes for the parent-child dyad could result. In the retrospective analysis, the researchers assessed outcomes among 149,790 singleton pregnancies delivered between June 1, 2016, and March 31, 2025
Constructs that include the disulfide bond (I317C/G361C) are much sharper in curve transition compared to the control (no mutation, black line)
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