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The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinsons disease and in neuronal injury following stroke. In fact, aging can result in a deficiency of glutathione, which can then lead to a number of other issues
1gi) was further confirmed by reciprocal immunoprecipitation: GFP-tagged FUS/TLS pulled down FLAG-tagged U1-70K and U1-A, and FLAG-tagged U1-70K and U1-A pulled down both GFP-tagged and endogenous FUS/TLS (Fig
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