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In vitro cAMP assay For GLP-1R agonist activity, CHOK1 cells stably expressing human GLP-1R were used to measure peptideantibody conjugate-induced cAMP production in a homogenous time-resolved fluorescence assay (Cisbio, cat
Previous studies have indicated an inconsistent relationship between metformins pharmacokinetic and pharmacodynamic responses [19] and metformin plasma concentrations vary widely at therapeutic doses with up to a 40-fold variation [35]
[9] Eder, K., Felgner, J., Becker, K., & Kluge, H
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