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The study period on medication or placebo following the lifestyle intervention is 72 weeks (84)

Hot flashes and night sweats are the most commonly reported symptom of the major hormonal transition into perimenopause and menopause

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Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis