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Some reports have suggested a potential increase in suicidality risk associated with semaglutide, though the preponderance of current evidence does not indicate a heightened risk ( 13 , 14 )
Despite this correlation, many of these studies lack detailed histopathological data on these pre-existing pigmentations, complicating a clear understanding of their role in melanoma development
Arguments for Game Changer Status Several compelling arguments support the characterization of GLP-1 agonists as transformative therapies: Unprecedented Efficacy : Tirzepatide marks a new era in overweight/obesity treatment, enabling many to achieve 20% weight loss [76] [77]
Implications for Plastic Surgery The growing use of GLP-1 RAs for the management of T2DM and weight loss is giving rise to a new patient population with distinct clinical needs
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