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- **Even Skin Tone:** Lightens dark spots and melasma, promoting a more even complexion
SIRT1, an NAD + -dependent deacetylase, regulates multiple critical processes, including lipid metabolism reprogramming, insulin signaling, oxidative stress response, autophagy, and immune balance, forming a regulatory network that spans metabolic, inflammatory, immune, and stress-related pathways
A 2023 study 24 showed that vitamin D may help enhance GLP-1 levels by improving the gut microbiome
Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]
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