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17 : E1458

Advances in experimental medicine and biology , 1032 , 37-53

Sporadic use delivers sporadic results

Some of the probable reasons for such moderation of GTIs with the FDC, beyond improved glycemic control, may be the interaction of DPP4 and SGLT2 proteins at the renal tubular cell-membrane level, or the inhibition of the DPP4 enzyme present in certain pathogenic microbes that may render them inactive (Fig