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In a study involving adolescents aged 12 to 18 years with a body mass index of 30 kg/m2 or higher, those who used liraglutide (3.0 mg) for 56 weeks showed a significant weight loss of 3.2%, as compared to a weight gain of 2.2% in the control group
This metabolic shift is highly problematic because anaerobic glycolysis produces only a fraction of the ATP generated by aerobic respiration, and it creates toxic byproducts in the process
Activation of GLP-1R attenuated CM-associated mechanical allodynia Considering the significant upregulation of GLP-1R in the TNC and the widely recognized effect of microglia in CM, it is reasonable to expect that GLP-1R may play an important role in the pathogenesis of CM
They might suggest additional testing, alternative medications, or lifestyle changes before beginning a GLP-1 medication
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