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The peptide's structure contains the 4-10 melanocortin receptor binding region common to -MSH and adrenocorticotropin (ACTH), but incorporates a lactam bridge between amino acids 4 and 10, along with specific amino acid substitutions (Nle4, Asp5, D-Phe7, Lys10) that enhance receptor binding affinity and metabolic stability
Ele foi identificado pela primeira vez na dcada de 1970, em estudos que observaram que tecidos humanos mais jovens apresentavam maior capacidade de regenerao quando expostos a esse complexo peptdico ligado ao cobre
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