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The aberrantly altered level of homocysteine (commonly hyperhomocysteinemia) triggers various pathological symptoms and subsequently the Hcy-related diseases

Am J Physiol Endocrinol Metab, 291(6), E1290E1294

Yes, MTHFR gene mutations can contribute to both anxiety and fatigue through several mechanisms: Anxiety: Impaired methylation reduces your bodys ability to produce adequate serotonin, dopamine, and GABA neurotransmitters that regulate mood and stress response