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In patients with diabetes, metformin therapy is consistently associated with a lower incidence of cardiovascular events compared with sulfonylureas or insulin, even with similar glycemic control (Hong et al., 2013), although one study reported reductions primarily in all-cause rather than cardiovascular mortality (Seifarth et al., 2013), thereby creating a favorable cardiometabolic milieu that may support downstream cardiovascular protection

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Zemdegs J, Martin H, Pintana H, Bullich S, Manta S, Marqus MA, et al

While everyones body responds differently, many people notice a positive change in their energy and mental clarity within 24 to 72 hours