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In the heart, the metabolome is characterized by amino acid depletion, evidence of altered redox balance including glutathione depletion, and a shift from oxidative phosphorylation to alternative energy production pathways
Consequently, the targeting of the Hippo/YAP pathway in conjunction with Gln metabolism inhibition may present a viable therapeutic approach for addressing tumors
Vitamin B12 injections should always be prescribed by a doctor, who can advise the dose, frequency of application and treatment duration, all which vary depending on the condition being treated
Proc Natl Acad Sci USA 99:30473051
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