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For example, the rs738409 variant in PNPLA3 , which has been linked to hepatic fat accumulation and metabolic dysfunction-associated steatotic liver disease, has also been associated with changes in taxa involved in fatty acid metabolism, including Bacteroidetes, Gemmiger , and Oscillospira ( GPR35 gene expression have been associated with increased abundance of Ruminococcus gnavus and hepatic fat accumulation, suggesting a potential link between host receptor signaling, gut microbial ecology, and liver metabolic phenotypes (Wu et al., 2023)

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The weight loss itself improves metabolic function, potentially reducing the dose required to maintain results