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Outside the brain, dopamine is synthesized in several tissues including the gastrointestinal system where its actions reduce gastrointestinal motility, the pancreas where its actions inhibit insulin synthesis, and in the kidneys where its actions increase sodium excretion and urinary output
Bellini G, Benvenuti L, Ippolito C, Frosini D, Segnani C, Rettura F, et al
461 However, during heart failure, decreased PKM1 and increased PKM2 levels are observed
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