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In mice, hepatocyte Dpp4 expression increases with obesity (82), and selective elimination of Dpp4 in the liver is associated with reduced levels of soluble DPP-4 in the plasma (82, 83)
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Secondary searches were performed using Google Scholar and regulatory sources, e.g., US Food and Drug Administration (FDA) labels and European Medicines Agency (EMA) reports, to capture gray literature and pharmacovigilance data
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