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Presented for research literature review only Nishino H et al

The debilitating, slow damage created by high levels of blood sugar (glucose) destroys everything from your blood vessels to your eyes, kidneys, and nerves over time due to oxidative stress (remember the free radicals or reactive oxygen species (ROS)?)

This paper reviews the key regulatory mechanism of insulin in bone regeneration and the characteristics of different insulin loaded nanoparticles, such as: (poly (lactic-co-glycolic acid), PLGA), hydroxyapatite (HA), gelatin, chitosan, alginate, and (-glutamic acid)/-tricalcium phosphate, -PGA/-TCP) (Figure 1)