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The peptide stimulates the activity of enzymes involved in ceramide biosynthesis, including serine palmitoyltransferase and ceramide synthase
Funding This work was supported in part by the Ministry of Science and Technology (2016YFA0502303 and 2015CB910300 to LL),the National Natural Science Foundation of China (21633001 to LL), and the Rudolf Virchow Jr
Both HOP and PP5 are co-chaperones of the HSP70 and HSP90 molecular chaperone systems, which assist in the maturation and activation of client proteins, such as glucocorticoid receptor (GR) in humans 26,37
Moreover, inflammatory markers IL-1 and TNF- decreased by 30 %, demonstrating measurable anti-inflammatory action
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