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It was determined that the +4 was the dominant charge state for each of the analytes monitored: Retatrutide 4731.3 Da= 1184 m/z Semaglutide 4113.6 Da= 1029 m/z Tirzepatide 4813.5 Da= 1204 m/z The charge state was determined by the following equation: The same method used for the LC-UV analysis was able to be applied to MS to achieve better sensitivity
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This decline correlates strongly with increased visceral fat accumulation
Knowles, P
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