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In connective tissue injury, the body must coordinate several processes: Inflammation modulation: The immune response must be strong enough to clear damaged tissue, but not so strong that it perpetuates breakdown

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The Atg7 protein is also essential for autophagy and mice that are knockout for this gene in the CNS show symptoms and signs that are similar to those evidenced during neurodegenerative disorders in humans, with significant neuronal loss in the cerebral and cerebellar cortices (Komatsu et al., 2006)