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Subsequently, NP4-Cy7.5 was intravenously injected into BALB/c mice, and the biodistribution of nanoparticles in mice was observed using an in vivo imaging system (IVIS)

In some studies, based on the intraperitoneal infusion of LPS in mice models, it was observed an increase in pro-inflammatory cytokines, such as IL8 and TNF alfa, but also the appearance of autoantibodies against ox LDL, the accumulation of inflammatory infiltrate in the vascular intima, and an increasing aortic atherosclerosis [64]

On the other hand, treatment with L-ca in a dose- dependent manner reduced the expression levels of caspase-9, NGAL, and KIM-1 compared to the MSG group and reversed its adverse effects