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Also, these effects can be attributed to direct action on GLP-1R in cardiac and vascular tissues [50]
In particular, the first study demonstrated that, along with improvements in anthropometric parameters, HOMA-IR reduced in both treatment arms, but liraglutide 1.2 mg/day was superior to metformin also in reducing glucose levels at 120 min during OGTT [57]
Also, the formula has been used safely for decades in medical settings
If the cold sensations are persistent or severe, be sure to discuss them with your healthcare provider for further guidance
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