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[27] Ceasing glutamine supplementation in people adapted to very high consumption may initiate a withdrawal effect, raising the risk of health problems such as infections or impaired integrity of the intestine
This response was more limited to the gut, so may have helped more in people with gastrointestinal issues like irritable bowel syndrome and Crohns
Consequently, metabolic demands are unmet, leading to sustained hypoperfusion, an inverse ischemic response, and the onset of new spreading ischemia
However, we cant draw any definitive conclusions from such small studies
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