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Dry eye disease Dry Eye Disease (DED) is a multifactorial condition of the ocular surface characterized by a loss of tear film homeostasis, with a particularly high prevalence among individuals with diabetes (Diabetic Dry Eye Syndrome, DDES) [118,119,120,121]

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Mitochondrial dysfunction is increasingly recognized as a contributor to neuropathy, particularly in diabetic and chemotherapy-induced forms where mitochondrial damage in dorsal root ganglion neurons precedes and contributes to axonal degeneration

TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/-catenin pathway