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Studies have also demonstrated that mice expressing ApoE4 in tauopathy models exhibit more severe tau-induced neurodegeneration compared to other isoforms, while mice lacking ApoE are protected from this effect (Shi et al., 2017)
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While secondary antioxidants may function by binding metal ions that can catalyze oxidative processes, absorbing UV radiation, blocking enzymes, or dissolving hydroperoxides, primary antioxidants typically function by giving a hydrogen atom [105]
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