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Goldspinks laboratory at the Medical College of Wisconsin has specifically characterised IGF-1 isoform activity in cardiac tissue, demonstrating MGFs role in preventing cardiomyocyte death, preserving contractility, and preventing pathological hypertrophy following myocardial infarction in animal studies

If metformin-associated lactic acidosis is suspected, immediately discontinue JANUMET and institute general supportive measures in a hospital setting

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Treated mice maintained normal blood glucose and insulin levels despite a fat-rich diet, indicating MOTS-cs potential to protect against obesity and metabolic syndrome