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If the 2-helix were to shift outward to a conformation more closely resembling that of OsDHAR1 or PgDHAR1, the steric hindrance would be relieved, allowing uncoiling of 1
The difference is that the retatrutide effect is sustained rather than transient
In Study 2, at Week 68, the body weight was missing for 7.2% and 11.9% of patients randomized to WEGOVY injection and placebo, respectively
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