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A study in the Journal of Controlled Release confirmed that microneedling enhances peptide penetration through the stratum corneum by up to 10-fold (PMC3016279)
doi:10.1359/JBMR.041018
Additionally, some methods are prohibited, such as blood doping and gene doping
Because BPC-157 appears to influence angiogenesis (blood vessel growth) in preclinical studies, there are theoretical concerns regarding its use in certain situations, including cancer
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