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Larger sustained increases warrant a clinician check
News Large-scale analysis of more than 400,000 Reddit posts has identified patient-reported symptoms associated with glucagon-like peptide-1 receptor agonists that may not be fully captured in clinical trials, with reproductive and temperature-related effects emerging as signals for further investigation in real world evidence A research team at the University of Pennsylvania, Philadelphia, USA, has used artificial intelligence to analyse more than 400,000 Reddit posts and identified patient-reported symptoms associated with glucagon-like peptide-1 (GLP-1) receptor agonists that may not have been explored in randomised clinical trials (RCTs) or regulatory documentation
"I don't have it," she says
Download our GLP-1 app to Turn Your Weight Loss Journey into Your Favorite Game Summary Diarrhea is a recognized semaglutide side effect, appearing in about 10% of patients in a 2025 Bayesian network meta-analysis and 10.6% in at least one cohort, so this side effect is measurable rather than rare complaints
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