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In practice, the greatest risk of adverse events happens among: People taking any dose of GLP-1 when they are not clinically indicated for the medication People taking compounded GLP-1 medications or GLP-1 medications that are not approved by the FDA People self-adjusting doses without physician oversight The Lure and Limits of Microdosing GLP-1s People who experience side effects from traditional GLP-1s may turn to microdosing in hopes of alleviating discomfort associated with nausea, diarrhea and vomiting