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The root of the tongue connects it to the jaw and to the hyoid bone, while the body stores on its surface four distinct lingual papillae, each with a unique anatomical and functional characteristic and an individual relationship with taste perception ( Figure 1 ) It is also important to highlight the complex neuronal architecture of the tongue, as we should consider three different innervation types: 1) Autonomic innervation: generates the salivatory stimuli and regulation of local blood flow, that plays an important role in food pleasure and avoidance ( C, A-, and A- fibers ( Figure 1 2.2 Taste receptor cells Taste buds are composed of distinct types of cells, some of them functioning as support cells, while there are others more specialized, named Taste Receptor Cells (TRC), which in turn, are divided in four categories

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Preclinical models show that GLP-1 agonists can reduce neuroinflammation by dampening microglial activation and decreasing pro-inflammatory cytokines, suggesting potential applications in protecting against neurodegenerative diseases like Alzheimer's and Parkinson's disease