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Notably, the LASSS-pretreatment displayed greater preventive effect on nitration of Y198 compared to Y250, as revealed by re-probing with anti-nitroY198 and Y250-HGF mAbs (Figure 2b, first and second rows, lanes 2 and 3
Binding to this allosteric site can still influence the sensitivity and activity of the receptor, but could lead to drugs with fewer off-target side-effects, since GLP-1 is involved in many different metabolic signalling pathways
Some people may notice mild digestive upset (e.g., nausea, cramps) or a temporary fishy odour at higher amounts
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