The antibody Fab7F38 appears to function by providing enhanced soluble surface area for crystal lattice packing, and indeed Fab7F38-bound GLP-1R can also assume an active conformation as shown by EM studies (see below), suggesting that Fab7F38 does not interfere with the conformational flexibility of the ECD during crystallization
Liddle C, Goodwin BJ, George J, Tapner M, Farrell GC
You get pharmaceutical-grade retatrutide for free, full medical supervision, and you contribute to the research that will determine whether the drug gets approved
Furthermore, recent studies show the benefits of tirzepatide in people with metabolic dysfunctionassociated steatohepatitis (MASH) [5], in people with heart failure with preserved ejection fraction (HFpEF) and obesity [6], and in people with T2D with established atherosclerotic cardiovascular disease according to a recent press release [7]