Subsequently, Nrf2 translocates from cytoplasm to the nucleus, forming heterodimers with other proteins to bind to EpRE
These include gastrointestinal issues (nausea, vomiting, diarrhea, constipation), pancreatitis, thyroid tumors, gallstones, hair loss, and mental health concerns
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More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]