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Briefly, aliquots of homogenate were protein-precipitated with 4% sulfosalicylic acid (SAS) (sample: SAS, 1:1 v/v), incubated at 4 C for 60 min and centrifuged at 12,000 g for 15 min at 4 C

While skin sensitivity from retatrutide is not an allergic reaction per se, antihistamines modulate histamine receptors in the skin that can amplify sensory signals

The scientific details are covered comprehensively in the published clinical trial literature see the Selected Research References at the end of this article

Other Possible Side Effects Less common side effects may include a faster heart rate, injection-site irritation, and problems linked to dehydration, especially if vomiting or diarrhea is severe