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3 We were doubly surprised when, after having first ventured that the effects of semaglutide on ASCVD were a function of the weight loss, a subsequent analysis found that weight loss or even change in waist circumference could only explain a small fraction of the effect (though the investigators didnt have direct measures of how much total or visceral adipose tissue the subjects lost)

Ozempic has shown a 59% resolution rate of steatohepatitis in trials, though fibrosis improvement was less clear