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It says microdosing is not appropriate for patients with severe renal impairment, a history of medullary thyroid carcinoma, or active gastroparesis, and states that pregnant or breastfeeding individuals should not use tirzepatide
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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation (Cheung et al., 2005)
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